Plancitoxin-1 mediates extracellular trap evasion by the parasitic helminth Trichinella spiralis.

ABSTRACT:

Background

Trichinella spiralis (T. spiralis) is a parasitic helminth that causes a globally prevalent neglected zoonotic disease, and worms at different developmental stages (muscle larvae, adult worms, newborn larvae) induce immune attack at different infection sites, causing serious harm to host health. Several innate immune cells release extracellular traps (ETs) to entrap and kill most pathogens that invade the body. In response, some unicellular pathogens have evolved a strategy to escape capture by ETs through the secretion of nucleases, but few related studies have investigated multicellular helminths.

Results

In the present study, we observed that ETs from neutrophils capture adult worms of T. spiralis, while ETs from macrophages trap muscle larvae and newborn larva

SUBMITTER: Ding J 

PROVIDER: S-EPMC11287892 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature