Is cross-species horizontal gene transfer responsible for gallbladder carcinogenesis.

ABSTRACT:

Background

Cross-species horizontal gene transfer (HGT) involves the transfer of genetic material between different species of organisms. In recent years, mounting evidence has emerged that cross-species HGT does take place and may play a role in the development and progression of diseases.

Methods

Transcriptomic data obtained from patients with gallbladder cancer (GBC) was assessed for the differential expression of antisense RNAs (asRNAs). The Basic Local Alignment Search Tool (BLAST) was used for cross-species analysis with viral, bacterial, fungal, and ancient human genomes to elucidate the evolutionary cross species origins of these differential asRNAs. Functional enrichment analysis and text mining were conducted and a network of asRNAs targeting mRNAs was constructed

SUBMITTER: Rajput M 

PROVIDER: S-EPMC11287962 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature