Spatial and temporal variation in respiratory syncytial virus (RSV) subtype RNA in wastewater and relation to clinical specimens.

ABSTRACT: Respiratory syncytial virus (RSV) causes a large burden of respiratory illness globally. It has two subtypes, RSV A and RSV B, but little is known regarding the predominance of these subtypes during different seasons and their impact on morbidity and mortality. Using molecular methods, we quantified RSV A and RSV B RNA in wastewater solids across multiple seasons and metropolitan areas to gain insight into the predominance of RSV subtypes. We determined the predominant subtype for each group using the proportion of RSV A to total RSV (RSV A + RSV B) in each wastewater sample (P_A,WW) and conducted a comparative analysis temporally, spatially, and against clinical specimens. A median P_A,WW of 0.00 in the first season and 0.58 in the second season indicated

SUBMITTER: Zambrana W 

PROVIDER: S-EPMC11288019 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature