Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling.

ABSTRACT:

Background

The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.

Results

Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib₁ and xib₁₃ with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing, we demonstrate that xib₁ and xib₁₃ inc

SUBMITTER: Pinheiro-Junior EL 

PROVIDER: S-EPMC11288129 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature