Genomic and Metagenomic Insights into the Distribution of Nicotine-degrading Enzymes in Human Microbiota.

ABSTRACT:

Introduction

Nicotine degradation is a new strategy to block nicotine-induced pathology. The potential of human microbiota to degrade nicotine has not been explored.

Aims

This study aimed to uncover the genomic potentials of human microbiota to degrade nicotine.

Methods

To address this issue, we performed a systematic annotation of Nicotine-Degrading Enzymes (NDEs) from genomes and metagenomes of human microbiota. A total of 26,295 genomes and 1,596 metagenomes for human microbiota were downloaded from public databases and five types of NDEs were annotated with a custom pipeline. We found 959 NdhB, 785 NdhL, 987 NicX, three NicA1, and three NicA2 homologs.

Results

Genomic classification revealed that six phylum-level taxa, including Proteobacteria, Fi

SUBMITTER: Guan Y 

PROVIDER: S-EPMC11288164 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature