Thioredoxin A regulates protein synthesis to maintain carbon and nitrogen partitioning in cyanobacteria.

ABSTRACT: Thioredoxins play an essential role in regulating enzyme activity in response to environmental changes, especially in photosynthetic organisms. They are crucial for metabolic regulation in cyanobacteria, but the key redox-regulated central processes remain to be determined. Physiological, metabolic, and transcriptomic characterization of a conditional mutant of the essential Synechocystis sp. PCC 6803 thioredoxin trxA gene (STXA2) revealed that decreased TrxA levels alter cell morphology and induce a dormant-like state. Furthermore, TrxA depletion in the STXA2 strain inhibited protein synthesis and led to changes in amino acid pools and nitrogen/carbon reserve polymers, accompanied by oxidation of the elongation factor-Tu. Transcriptomic analysis of TrxA depletion in STXA2 revealed a robus

SUBMITTER: Mallen-Ponce MJ 

PROVIDER: S-EPMC11288746 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature