Genomic study of Acinetobacter baumannii strains co-harboring bla _OXA-58 and bla _NDM-1 reveals a large multidrug-resistant plasmid encoding these carbapenemases in Brazil.

ABSTRACT:

Introduction

Acinetobacter baumannii contributes significantly to the global issue of multidrug-resistant (MDR) nosocomial infections. Often, these strains demonstrate resistance to carbapenems (MDR-CRAB), the first-line treatment for infections instigated by MDR A. baumannii. Our study focused on the antimicrobial susceptibility and genomic sequences related to plasmids from 12 clinical isolates of A. baumannii that carry both the blaOXA-58 and bla _NDM-1 carbapenemase genes.

Methods

Whole-genome sequencing with long-read technology was employed for the characterization of an A. baumannii plasmid that harbors the bla _OXA-58 and blaNDM-1 genes. The location of the bla _OXA-58 and bla _NDM-1</

SUBMITTER: Rodrigues DCS 

PROVIDER: S-EPMC11288812 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature