Integrative single-cell analysis of longitudinal t(8;21) AML reveals heterogeneous immune cell infiltration and prognostic signatures.

ABSTRACT:

Introduction

Immunotherapies targeting T cells in solid cancers are revolutionizing clinical treatment. Novel immunotherapies have had extremely limited benefit for acute myeloid leukemia (AML). Here, we characterized the immune microenvironment of t(8;21) AML patients to determine how immune cell infiltration status influenced prognosis.

Methods

Through multi-omics studies of primary and longitudinal t(8;21) AML samples, we characterized the heterogeneous immune cell infiltration in the tumor microenvironment and their immune checkpoint gene expression. Further external cohorts were also included in this research.

Results

CD8+ T cells were enriched and HAVCR2 and TIGIT were upregulated in the CD34⁺CD117^dim%-High group; these featur

SUBMITTER: Li XP 

PROVIDER: S-EPMC11288856 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature