Comparative genomics between Trichomonas tenax and Trichomonas vaginalis: CAZymes and candidate virulence factors.

ABSTRACT:

Introduction

The oral trichomonad Trichomonas tenax is increasingly appreciated as a likely contributor to periodontitis, a chronic inflammatory disease induced by dysbiotic microbiota, in humans and domestic animals and is strongly associated with its worst prognosis. Our current understanding of the molecular basis of T. tenax interactions with host cells and the microbiota of the oral cavity are still rather limited. One laboratory strain of T. tenax (Hs-4:NIH/ATCC 30207) can be grown axenically and two draft genome assemblies have been published for that strain, although the structural and functional annotation of these genomes is not available.

Methods

GenSAS and Galaxy were used to annotate two publicly available draft genomes for T. tenax, with a

SUBMITTER: Mpeyako LA 

PROVIDER: S-EPMC11288935 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature