The genetic relationship between hypotension and delirium: a Mendelian randomization study.

ABSTRACT:

Background

Observational research suggests that hypotension is a potential hazard factor of delirium. Nevertheless, previous observational articles are limited in their ability to establish causality between hypotension and delirium. The present study was sought to explore the genetic causal relationship between these two conditions using two-sample Mendelian randomization (MR).

Methods

Genome-wide association study (GWAS) summarized data for hypotension and delirium were obtained from the FinnGen Consortium. The researchers utilized several statistical methods, such as inverse-variance weighted (IVW), weighted median, MR Egger, weighted mode, and simple mode in conducting the MR statistical analysis. In order to identify heterogeneity among the MR outcomes, we employed the

SUBMITTER: Wang C 

PROVIDER: S-EPMC11288944 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature