Associations between interleukin-10, -12, and - 18 and periodontal health and disease: a cross-sectional study.

ABSTRACT:

Objective

We assessed the levels of Interleukin-10 (IL-10), Interleukin-12 (IL-12), and Interleukin-18 (IL-18) in the gingival crevicular fluid (GCF) of subjects with advanced periodontitis (SIII-SIV) compared to healthy controls and evaluated their correlations with clinical measurements.

Methods

This cross-sectional study involved subjects (n = 60) diagnosed with stage III grade B-C (n = 13) to stage IV grade C (n = 17) periodontitis, and periodontally healthy controls (n = 30). Clinical periodontal measurements involved full-mouth. The concentrations of IL-10, IL-12, and IL-18 were determined using enzyme-linked immunosorbent assay (ELISA).

Results

There were no significant differences in IL-12 level and IL-18/IL-10 ratio between the healthy and periodontitis group

SUBMITTER: Cebesoy EI 

PROVIDER: S-EPMC11289060 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature