Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression.

ABSTRACT: The brain and immune system communicate through complex bidirectional pathways, but the specificity by which the brain perceives or even remembers alterations in immune homeostasis is still poorly understood. Recent data revealed that immune-related information under peripheral inflammatory conditions, termed as "immunengram", were represented in specific neuronal ensembles in the insular cortex (IC). Chemogenetic reactivation of these neuronal ensembles was sufficient to retrieve the inflammatory stages, indicating that the brain can store and retrieve specific immune responses. Against this background, the current approach was designed to investigate the ability of the IC to process states of immunosuppression pharmacologically induced by the mechanistic target of rapamycin (mTOR) inhibi

SUBMITTER: Bihorac J 

PROVIDER: S-EPMC11289148 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature