Diffusion Tensor Imaging for Characterizing Changes in Triple-Negative Breast Cancer During Neoadjuvant Systemic Therapy.

ABSTRACT:

Background

Assessment of treatment response in triple-negative breast cancer (TNBC) may guide individualized care for improved patient outcomes. Diffusion tensor imaging (DTI) measures tissue anisotropy and could be useful for characterizing changes in the tumors and adjacent fibroglandular tissue (FGT) of TNBC patients undergoing neoadjuvant systemic treatment (NAST).

Purpose

To evaluate the potential of DTI parameters for prediction of treatment response in TNBC patients undergoing NAST.

Study type

Prospective.

Population

Eighty-six women (average age: 51 ± 11 years) with biopsy-proven clinical stage I-III TNBC who underwent NAST followed by definitive surgery. 47% of patients (40/86) had pathologic complete response (pCR).

Field strength/sequence

3.0 

SUBMITTER: Musall BC 

PROVIDER: S-EPMC11289164 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature