Structure of the MlaC-MlaD complex reveals molecular basis of periplasmic phospholipid transport.

ABSTRACT: The Maintenance of Lipid Asymmetry (Mla) pathway is a multicomponent system found in all gram-negative bacteria that contributes to virulence, vesicle blebbing and preservation of the outer membrane barrier function. It acts by removing ectopic lipids from the outer leaflet of the outer membrane and returning them to the inner membrane through three proteinaceous assemblies: the MlaA-OmpC complex, situated within the outer membrane; the periplasmic phospholipid shuttle protein, MlaC; and the inner membrane ABC transporter complex, MlaFEDB, proposed to be the founding member of a structurally distinct ABC superfamily. While the function of each component is well established, how phospholipids are exchanged between components remains unknown. This stands as a major roadblock in our understan

SUBMITTER: Wotherspoon P 

PROVIDER: S-EPMC11289387 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature