Genetic support for the causal association between 91 circulating inflammatory proteins and atopic dermatitis: A two-sample Mendelian randomization trial.

ABSTRACT:

Background

Atopic dermatitis (AD) is a refractory disease that occurs in clinical practice. One of the most common inflammatory skin diseases, its occurrence and development are related to inflammation. Nevertheless, the precise nature of the relationship between circulating inflammatory proteins and AD remains uncertain.

Methods

A two-sample MR analysis was performed to determine the causal relationship between the expression of 91 circulating inflammatory proteins and AD by using genome-wide association study (GWAS) summary statistics data from the FinnGen consortia. The robustness of the MR results was assessed by means of sensitivity analysis.

Results

The causal relationship between the expression of nine specific circulating inflammatory proteins and AD was corro

SUBMITTER: Du X 

PROVIDER: S-EPMC11289424 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature