All organic nanomedicine for PDT-PTT combination therapy of cancer cells in hypoxia.

ABSTRACT: Photodynamic and photothermal therapies are promising treatments for cancer, dermatological, and ophthalmological conditions. However, photodynamic therapy (PDT) is less effective in oxygen-deficient tumor environments. Combining PDT with photothermal therapy (PTT) can enhance oxygen supply and treatment efficacy. Inorganic PTT agents pose toxicity risks, limiting their clinical use despite their high performance. In this study, we developed a novel nanomedicine integrating an all-organic photothermal agent and an organic photosensitizer, creating a colocalized nanoplatform to enhance phototherapy efficacy in cancer treatment. PTT nanoparticles (NPs) were synthesized through a thermal phase transition of organic chromophores, demonstrating superior photothermal properties and photostabilit

SUBMITTER: Urazaliyeva A 

PROVIDER: S-EPMC11289472 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature