Comprehensive proteomic analysis of the differential expression of 62 proteins following intracortical microelectrode implantation.

ABSTRACT: Intracortical microelectrodes (IMEs) are devices designed to be implanted into the cerebral cortex for various neuroscience and neuro-engineering applications. A critical feature of IMEs is their ability to detect neural activity from individual neurons. Currently, IMEs are limited by chronic failure, largely considered to be caused by the prolonged neuroinflammatory response to the implanted devices. Over the past few years, the characterization of the neuroinflammatory response has grown in sophistication, with the most recent advances focusing on mRNA expression following IME implantation. While gene expression studies increase our broad understanding of the relationship between IMEs and cortical tissue, advanced proteomic techniques have not been reported. Proteomic evaluation is neces

SUBMITTER: Song SS 

PROVIDER: S-EPMC11289480 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature