Long-term outcomes and predictors of vedolizumab persistence in ulcerative colitis.

ABSTRACT:

Background

Long-term vedolizumab (VDZ) outcomes in real-world cohorts have been largely limited to 1-year follow-up, with few bio-naïve patients or objective markers of inflammation assessed.

Objectives

We aimed to assess factors affecting VDZ persistence including clinical, biochemical and faecal biomarker remission at 1, 3 and 5 years.

Design

We performed a retrospective, observational, cohort study.

Methods

All adult inflammatory bowel disease (IBD) patients who had received VDZ induction for ulcerative colitis (UC)/IBD-unclassified (IBDU) were included. Baseline phenotype and follow-up data were collected via a review of electronic medical records.

Results

We included 290 patients [UC n = 271 (93.4%), IBDU n = 19 (6.6%)] with a m

SUBMITTER: Gros B 

PROVIDER: S-EPMC11289824 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature