Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis.

ABSTRACT:

Background

The causal associations between dietary intake and the risk and severity of Inflammatory Arthritis (IA) are currently unknown.

Objective

In this study, we aimed to investigate the causal relationship between nine dietary categories (30 types of diet) and IA using Mendelian randomization (MR).

Methods

We analyzed data from 30 diets and IA in a genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) that could influence the results of MR analyses were screened out through the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. SNPs were analyzed through two-sample bidirectional MR using inverse variance weighting, MR-Egger regression, and weighted median method. The multiplicity and heterogeneity of SNPs were ass

SUBMITTER: Wang H 

PROVIDER: S-EPMC11289845 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature