Oncostatin M-driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis.

ABSTRACT:

Background

Recent single-cell RNA sequencing (scRNA-seq) analysis revealed the functional heterogeneity and pathogenic cell subsets in immune cells, synovial fibroblasts and bone cells in rheumatoid arthritis (RA). JAK inhibitors which ameliorate joint inflammation and bone destruction in RA, suppress the activation of various types of cells in vitro. However, the key cellular and molecular mechanisms underlying the potent clinical effects of JAK inhibitors on RA remain to be determined. Our aim is to identify a therapeutic target for JAK inhibitors in vivo.

Methods

We performed scRNA-seq analysis of the synovium of collagen-induced arthritis (CIA) mice treated with or without a JAK inhibitor, followed by a computational analysis to identify the drug target cells and signali

SUBMITTER: Huynh NC 

PROVIDER: S-EPMC11289929 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature