Effects of stress-related neuromodulators on amygdala and hippocampus resting state functional connectivity.

ABSTRACT:

Background

The human stress response is characterized by increases in neuromodulators, including norepinephrine (NE) and cortisol. Both neuromodulators can enter the brain and affect neurofunctional responses. Two brain areas associated with stress are the amygdala and the hippocampus. The precise influence of NE and cortisol on the amygdala and hippocampal resting state functional connectivity (RSFC) is poorly understood.

Aims

To investigate the influence of NE and cortisol on the amygdala and hippocampal RSFC.

Methods

We recruited 165 participants who received 10 mg yohimbine and/or 10 mg hydrocortisone in a randomized, placebo-controlled design. With seed-based analyses, we compared RSFC of the hippocampus and amygdala separately between the three groups that recei

SUBMITTER: Rosada C 

PROVIDER: S-EPMC11290027 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature