Targeting tumor-infiltrating CCR8⁺ regulatory T cells induces antitumor immunity through functional restoration of CD4⁺ T_convs and CD8⁺ T cells in colorectal cancer.

ABSTRACT:

Background

Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8⁺ Tregs observed in breast and lung malignancies suggest for their functional significance in cancer therapy. To date, detailed characterization of tumor-infiltrating CCR8⁺ Tregs cells in colorectal cancer (CRC) is limited.

Methods

To study the presence and functional involvement of CCR8⁺ Tregs in CRC, we analyzed the proportions of CCR8-expressing T cells in different T cell subsets in tumor and adjacent normal tissues and peripheral blood mononuclear cells (PBMCs) from CRC patients by Flow cytometry. Also, we compared the distribution of CCR8⁺ T

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11290082 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature