CD71 + erythroid cells promote intestinal symbiotic microbial communities in pregnancy and neonatal period.

ABSTRACT:

Background

The establishment of microbial communities in neonatal mammals plays a pivotal role in shaping their immune responses to infections and other immune-related conditions. This process is influenced by a combination of endogenous and exogenous factors. Previously, we reported that depletion of CD71 + erythroid cells (CECs) results in an inflammatory response to microbial communities in newborn mice.

Results

Here, we systemically tested this hypothesis and observed that the small intestinal lamina propria of neonatal mice had the highest frequency of CECs during the early days of life. This high abundance of CECs was attributed to erythropoiesis niches within the small intestinal tissues. Notably, the removal of CECs from the intestinal tissues by the anti-CD71 antibo

SUBMITTER: Koleva P 

PROVIDER: S-EPMC11290123 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature