Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer's disease.

ABSTRACT:

Background

It is not fully established whether plasma β-amyloid(Aβ)₄₂/Aβ₄₀ and phosphorylated Tau₁₈₁ (p-Tau₁₈₁) can effectively detect Alzheimer's disease (AD) pathophysiology in older Chinese adults and how these biomarkers correlate with astrocyte reactivity, Aβ plaque deposition, tau tangle aggregation, and neurodegeneration.

Methods

We recruited 470 older adults and analyzed plasma Aβ₄₂/Aβ₄₀, p-Tau₁₈₁, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) using the Simoa platform. Among them, 301, 195, and 70 underwent magnetic resonance imaging, Aβ and tau positron emission tomography imaging. The plasma Aβ₄₂/Aβ₄₀ and p-Tau₁₈₁ thresholds were def

SUBMITTER: Guo T 

PROVIDER: S-EPMC11290175 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature