Highly homologous simian T-cell leukemia virus type 1 genome in Japanese macaques: a large cohort study.

ABSTRACT:

Background

Simian T-cell leukemia virus type 1 (STLV-1) is a retrovirus closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia (ATL). It has been shown that Japanese macaques (Macaca fuscata, JMs) are one of the main hosts of STLV-1 and that a high percentage of JMs (up to 60%) are infected with STLV-1; however, the molecular epidemiology of STLV-1 in JMs has not been examined.

Methods

In this study, we analyzed full-length STLV-1 genome sequences obtained from 5 independent troops including a total of 68 JMs.

Results

The overall nucleotide heterogeneity was 4.7%, and the heterogeneity among the troops was 2.1%, irrespective of the formation of distinct subclusters in each troop. Moreover, the heterogeneity within

SUBMITTER: Hiraga K 

PROVIDER: S-EPMC11290215 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature