Differences in maternal-newborn ABO blood groups and risk of serious infant infection.

ABSTRACT:

Background

During pregnancy, various maternal IgG antibodies are transferred to the developing fetus, some of which may protect the newborn against infection. If a mother and her fetus have different A, B or O (ABO) blood groups, then transferred maternal antibodies may plausibly protect the infant against infection.

Aim

To determine if maternal-newborn ABO blood group incongruence vs. congruence is associated with a lower risk of serious infection in the infant.

Design

Retrospective population-based cohort.

Methods

We used linked patient-level datasets for all singleton hospital livebirths from 2008 to 2022 in Ontario, Canada, with known maternal and newborn ABO blood groups. We used a dichotomous exposure state, either ABO blood group congruent (N = 114 507)

SUBMITTER: Butler EA 

PROVIDER: S-EPMC11290255 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature