Environmental, socioeconomic, and health factors associated with gut microbiome species and strains in isolated Honduras villages.

ABSTRACT: Despite a growing interest in the gut microbiome of non-industrialized countries, data linking deeply sequenced microbiomes from such settings to diverse host phenotypes and situational factors remain uncommon. Using metagenomic data from a community-based cohort of 1,871 people from 19 isolated villages in the Mesoamerican highlands of western Honduras, we report associations between bacterial species and human phenotypes and factors. Among them, socioeconomic factors account for 51.44% of the total associations. Meta-analysis of species-level profiles across several datasets identified several species associated with body mass index, consistent with previous findings. Furthermore, the inclusion of strain-phylogenetic information modifies the overall relationship between the gut microbiom

SUBMITTER: Shridhar SV 

PROVIDER: S-EPMC11290354 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature