Multiphoton tandem photoredox catalysis of [Ir(dFCF3ppy)2(dtbbpy)]+ facilitating radical acylation reactions.

ABSTRACT: Photoredox catalytic radical acylation reactions, utilizing [Ir(dFCF3ppy)2(dtbbpy)]+ (IrIII) as the photocatalyst and α-keto acids as the starting substrates, have recently emerged as an attractive strategy for preparing ketone derivatives. While there is consensus on the importance of detailed mechanistic insights to maximize the formation of desired products, efforts focused on uncovering the underlying elementary mechanisms of IrIII photocatalytic radical acylation reactions are still lacking. Herein, using time-resolved spectroscopy, we observed the efficient quenching of the triplet state, 3IrIII*, via electron transfer from α-keto acids, resulting in the generatation of the reduced IrII. Subsequently, IrII rapidly transforms into a stable IrH+ species through protonation, with α-keto

SUBMITTER: Lin Z 

PROVIDER: S-EPMC11290445 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature