Regulation of microtubule dynamics and function in living cells via cucurbit[7]uril host-guest assembly.

ABSTRACT: Living systems utilize sophisticated biochemical regulators and various signal transduction mechanisms to program bio-molecular assemblies and their associated functions. Creating synthetic assemblies that can replicate the functional and signal-responsive properties of these regulators, while also interfacing with biomolecules, holds significant interest within the realms of supramolecular chemistry and chemical biology. This pursuit not only aids in understanding the fundamental design principles of life but also introduces novel capabilities that contribute to the advancements in medical and therapeutic research. In this study, we present a cucurbit[7]uril (CB[7]) host-guest system designed to regulate the dynamics and functions of microtubules (MTs) in living cells. To establish commun

SUBMITTER: Saroha A 

PROVIDER: S-EPMC11290447 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature