Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging.

ABSTRACT:

Introduction

The "structural disconnection" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive.

Methods

We examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20-79). We used the Virginia Cognitive Aging Project and the NIH Toolbox® to generate composites for memory, processing speed, and executive function.

Results

Voxel-wise analyses showed that lower myelin water fraction (MWF), predominantly in prefrontal WM, genu of the corpus callosum, and posterior limb of the internal capsule was associated with reduced memory performance after controlling for age, sex, and educatio

SUBMITTER: Mendez Colmenares A 

PROVIDER: S-EPMC11290458 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature