Functional cure and long-term survival in multiple myeloma: how to challenge the previously impossible.

ABSTRACT: Multiple myeloma (MM) is a heterogeneous disease with survival ranging from months to decades. The goal of 'cure' remains elusive for most patients, but has been shown to be possible, with durable remission and a transition to a plateau phase (analogous to monoclonal gammopathy of uncertain significance/smoldering myeloma). In this review, two representative cases set the stage to illustrate how this might be possible and what still needs to be determined to achieve functional disease control over a prolonged period. Several developments have emerged, such as improved diagnostics including the definitions and use of SLiM-CRAB criteria and measurable residual disease (MRD) with whole-genome/single-cell sequencing as well as other correlates to better understand disease biology. These advanc

SUBMITTER: Engelhardt M 

PROVIDER: S-EPMC11290544 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature