Integrated multi-omics profiling landscape of organising pneumonia.

ABSTRACT:

Background

Organising pneumonia (OP) is one of the most common and lethal diseases in the category of interstitial pneumonia, along with lung cancer. Reprogramming of lipid metabolism is a newly recognized hallmark of many diseases including cancer, cardiovascular disorders, as well as liver fibrosis and sclerosis. Increased levels of ceramides composed of sphingosine and fatty acid, are implicated in the development of both acute and chronic lung diseases. However, their pathophysiological significance in OP is unclear. The aim of this study was to investigate the role of lipid metabolism reprogramming in OP, focusing on inflammation and fibrosis.

Methods

Comprehensive multi-omics profiling approaches, including single-cell RNA sequencing, Visium CytAssist spatial transcrip

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11290555 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature