Optimising primary molecular profiling in non-small cell lung cancer.

ABSTRACT:

Introduction

Molecular profiling of NSCLC is essential for optimising treatment decisions, but often incomplete. We assessed the efficacy of protocolised molecular profiling in the current standard-of-care (SoC) in a prospective observational study in the Netherlands and measured the effect of providing standardised diagnostic procedures. We also explored the potential of plasma-based molecular profiling in the primary diagnostic setting.

Methods

This multi-centre prospective study was designed to explore the performance of current clinical practice during the run-in phase using local SoC tissue profiling procedures. The subsequent phase was designed to investigate the extent to which comprehensive molecular profiling (CMP) can be maximized by protocolising tumour profiling.

SUBMITTER: Schouten RD 

PROVIDER: S-EPMC11290658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature