Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?

ABSTRACT: A hallmark of Parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher prevalence to degenerate than those located in the dorsal tier. The underlying reasons for this selective neuronal vulnerability are still unknown. The aim of the present study was to gain a better understanding of molecular differences between these two neuronal subpopulations that may explain the selective neuronal vulnerability within the human substantia nigra. For this purpose, the neurons from the ventral as well as dorsal tier of the substantia nigra were specifically isolated out

SUBMITTER: Steinbach S 

PROVIDER: S-EPMC11290673 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature