A Polygenic Risk Score for Predicting Racial and Genetic Susceptibility to Prurigo Nodularis.

ABSTRACT: Prurigo nodularis (PN) is an understudied inflammatory skin disease characterized by pruritic, hyperkeratotic nodules. Identifying the genetic factors underlying PN could help to better understand its etiology and guide the development of therapies. In this study, we developed a polygenic risk score that predicts a diagnosis of PN (OR = 1.41, P = 1.6 × 10^-5) in two independent and continentally distinct populations. We also performed GWASs, which uncovered genetic variants associated with PN, including one near PLCB4 (rs6039266: OR = 3.15, P = 4.8 × 10^-8) and others near TXNRD1 (rs34217906: OR = 1.71, P = 6.4 × 10^-7; rs7134193: OR = 1.57, P = 1.1 × 10^-6). Finally, we discovered that Black patients have over a two-times greater genetic risk of dev

SUBMITTER: Vasavda C 

PROVIDER: S-EPMC11290854 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature