The impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs.

ABSTRACT:

Background

In South Africa, an estimated 11% of the population have high alcohol use, a major risk factor for TB. Alcohol and other substance use are also associated with poor treatment response, with a potential mechanism being altered TB drug pharmacokinetics.

Objectives

To investigate the impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs in participants with pulmonary TB.

Methods

We prospectively enrolled participants ≥15 years old, without HIV, and initiating drug-susceptible TB treatment in Worcester, South Africa. Alcohol use was measured via self-report and blood biomarkers. Other illicit substances were captured through a urine drug test. Plasma samples were drawn 1 month into treatment pre-dose, and 1.5, 3, 5 and 8 h p

SUBMITTER: Wijk M 

PROVIDER: S-EPMC11290884 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature