Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties.

ABSTRACT:

Background

Intracellular magnesium is abundant, highly regulated and plays an important role in biochemical functions. Despite the extensive evidence for unique mammalian Mg2+ transporters, few proteins have been biochemically identified to date that fulfill this role. We have shown that epithelial magnesium conservation is controlled, in part, by differential gene expression leading to regulation of Mg2+ transport. We used this knowledge to identify a novel gene that is regulated by magnesium.

Results

Oligonucleotide microarray analysis was used to identify a novel human gene that encodes a protein involved with Mg2+-evoked transport. We have designated this magnesium transporter (MagT1) protein. MagT1 is a novel protein with no amino acid sequence identity to other known t

SUBMITTER: Goytain A 

PROVIDER: S-EPMC1129089 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature