Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment.

ABSTRACT: Human Accelerated Regions (HARs) are highly conserved across species but exhibit a significant excess of human-specific sequence changes, suggesting they may have gained novel functions in human evolution. HARs include transcriptional enhancers with human-specific activity and have been implicated in the evolution of the human brain. However, our understanding of how HARs contributed to uniquely human features of the brain is hindered by a lack of insight into the genes and pathways that HARs regulate. It is unclear whether HARs acted by altering the expression of gene targets conserved between HARs and their chimpanzee orthologs or by gaining new gene targets in human, a mechanism termed enhancer hijacking. We generated a high-resolution map of chromatin interactions for 1,590 HARs and th

SUBMITTER: Pal A 

PROVIDER: S-EPMC11291010 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature