CoDIAC: A comprehensive approach for interaction analysis reveals novel insights into SH2 domain function and regulation.

ABSTRACT: Protein domains are conserved structural and functional units that serve as building blocks of proteins. Through evolutionary expansion, domain families are represented by multiple members in diverse configurations with other domains, evolving new specificities for their interacting partners. Here, we develop a structure-based interface analysis to comprehensively map domain interfaces from experimental and predicted structures, including interfaces with macromolecules and intraprotein interfaces. We hypothesized that comprehensive contact mapping of domains could yield new insights into domain selectivity, conservation of domain-domain interfaces across proteins, and identify conserved post-translational modifications (PTMs), relative to interaction interfaces, allowing for the inference

SUBMITTER: Kandoor A 

PROVIDER: S-EPMC11291013 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature