Temporal Transcriptomic Profiling of the Developing <i>Xenopus laevis</i> Eye.

ABSTRACT: Retinal progenitor cells (RPCs) are a multipotent and highly proliferative population that give rise to all retinal cell types during organogenesis. Defining their molecular signature is a key step towards identifying suitable approaches to treat visual impairments. Here, we performed RNA-sequencing of whole eyes from Xenopus at three embryonic stages and used differential expression analysis to define the transcriptomic profiles of optic tissues containing proliferating and differentiating RPCs during retinogenesis. Gene Ontology and KEGG pathway analyses showed that genes associated with developmental pathways (including Wnt and Hedgehog signaling) were upregulated during the period of active RPC proliferation in early retinal development (Nieuwkoop Faber st. 24 and 27). Developin

SUBMITTER: Hack SJ 

PROVIDER: S-EPMC11291033 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature