The Genetic Architecture of the Human Corpus Callosum and its Subregions.

ABSTRACT: The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses, performing associative/executive functions, and representing information in multiple dimensions. Understanding which genetic variants underpin corpus callosum morphometry, and their shared influence on cortical structure and susceptibility to neuropsychiatric disorders, can provide molecular insights into the CC's role in mediating cortical development and its contribution to neuropsychiatric disease. To characterize the morphometry of the midsagittal corpus callosum, we developed a publicly available artificial intelligence based tool to extract, parcellate, and calculate its total and regional area and thicknes

SUBMITTER: Bhatt RR 

PROVIDER: S-EPMC11291056 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature