The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex.

ABSTRACT: Circular RNAs (circRNAs) are a class of closed-loop, single stranded RNAs whose expression is particularly enriched in the brain. Despite this enrichment and evidence that the expression of circRNAs are altered by synaptic development and in response to synaptic plasticity in vitro, the regulation by and function of the majority of circRNAs in experience-dependent plasticity in vivo remain unexplored. Here, we employed transcriptome-wide analysis comparing differential expression of both mRNAs and circRNAs in juvenile mouse primary visual cortex (V1) following monocular deprivation (MD), a model of experience-dependent developmental plasticity. Among the differentially expressed mRNAs and circRNAs following 3-day MD, the circular and the activity-dependent mRNA forms of the <

SUBMITTER: Jenks KR 

PROVIDER: S-EPMC11291094 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature