<i>In vivo</i> quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics.

ABSTRACT:

Purpose

Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometery. Analyzing fluorophotometric data depends, inter alia, on the volume of aqueous humor in the anterior, but not the posterior, chamber. Previous fluorophotometric studies of aqueous inflow rate in mice have assumed the ratio of anterior:posterior volumes in mice to be similar to those in humans. Our goal was to measure anterior and posterior chamber volumes in mice to facilitate better estimates of aqueous inflow rates.

Methods

We used standard near-infrared optical coherence tomography (OCT) and robotic visible-light OCT (vis-OCT) to visualize, reconstruct and quantify the volumes of the anterior and posterior chambers of the mouse eye i

SUBMITTER: Kim D 

PROVIDER: S-EPMC11291131 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature