Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity.

ABSTRACT: Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue - an essential consideration when developing effective methods to treat such injuries - has been limited by a lack of robust genetically tractable models. Our lab previously established a method to study necrosis-induced regeneration in the Drosophila wing imaginal disc, which revealed a unique phenomenon whereby cells at a distance from the injury upregulate caspase activity in a process called Necrosis-induced Apoptosis (NiA) that is vital for regeneration. Here we have further investigated this phenomenon, showing that NiA is predominantly associated with the highly regenerative pouch region of the disc, sha

SUBMITTER: Klemm JW 

PROVIDER: S-EPMC11291143 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature