Entorhinal cortex represents task-relevant remote locations independent of CA1.

ABSTRACT: Neurons can collectively represent the current sensory experience while an animal is exploring its environment or remote experiences while the animal is immobile. These remote representations can reflect learned associations^1-3 and be required for learning⁴. Neurons in the medial entorhinal cortex (MEC) reflect the animal's current location during movement⁵, but little is known about what MEC neurons collectively represent during immobility. Here, we recorded thousands of neurons in superficial MEC and dorsal CA1 as mice learned to associate two pairs of rewarded locations. We found that during immobility, the MEC neural population frequently represented positions far from the animal's location, which we defined as 'non-local coding'. Cells with spatial fir

SUBMITTER: Jones EAA 

PROVIDER: S-EPMC11291150 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature