The axillary lymphoid organ - an external, experimentally accessible immune organ in the zebrafish.

ABSTRACT: Lymph nodes and other secondary lymphoid organs play critical roles in immune surveillance and immune activation in mammals, but the deep internal locations of these organs make it challenging to image and study them in living animals. Here, we describe a previously uncharacterized external immune organ in the zebrafish ideally suited for studying immune cell dynamics in vivo, the axillary lymphoid organ (ALO). This small, translucent organ has an outer cortex teeming with immune cells, an inner medulla with a mesh-like network of fibroblastic reticular cells along which immune cells migrate, and a network of lymphatic vessels draining to a large adjacent lymph sac. Noninvasive high-resolution imaging of transgenically marked immune cells can be carried out in the lobes of living an

SUBMITTER: Castranova D 

PROVIDER: S-EPMC11291151 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature