Multivariate Neural Patterns of Reward and Anxiety in Adolescents with Anorexia Nervosa.

ABSTRACT: People with anorexia nervosa (AN) commonly exhibit elevated anxiety and atypical reward responsiveness. To examine multivariate neural patterns associated with reward and the impact of anxiety on reward, we analyzed fMRI data from a monetary reward task using representational similarity analysis, a multivariate approach that measures trial-by-trial consistency of neural responses. Twenty-five adolescent girls with AN and 22 mildly anxious controls lacking any history of AN were presented personalized anxiety-provoking or neutral words before receiving a reward, and neural response patterns in reward regions were analyzed. Consistent with our preregistered hypothesis, AN participants showed lower representational similarity than controls during neutral-word rewarded trials. Within groups, c

SUBMITTER: Peel HJ 

PROVIDER: S-EPMC11291162 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature