Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats.

ABSTRACT: Sex differences in oxidative stress-associated cognitive decline are influenced by sex hormone levels. Notably, oxidative stress-associated neuronal cell death can be exacerbated through testosterone signaling via membrane androgen receptor AR45, which is complexed with G protein Gαq within plasma membrane-associated lipid rafts. The objective of this study was to elucidate the impact of sex on the expression of AR45 and Gαq in brain regions associated with cognitive function, specifically hippocampus subregions and entorhinal cortex. Additionally, we investigated whether chronic intermittent hypoxia (CIH), an oxidative stressor with sex-specific effects, would modulate AR45 and Gαq expression in these brain regions. Adult male and female Sprague-Dawley rats were exposed to CIH or normoxia

SUBMITTER: Bradshaw JL 

PROVIDER: S-EPMC11291194 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature