Causal relationship between type 2 diabetes and common respiratory system diseases: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Type 2 diabetes (T2D) frequently co-occurs with respiratory system diseases such as chronic obstructive pulmonary disease (COPD), bronchial asthma, lung cancer, interstitial lung disease, and pulmonary tuberculosis. Although a potential association is noted between these conditions, the available research is limited.

Objective

To investigate the causal relationship between patients with T2D and respiratory system diseases using two-sample Mendelian randomization analysis.

Methods

Causal relationships were inferred using a two-sample Mendelian randomization (MR) analysis based on publicly available genome-wide association studies. We employed the variance inverse-weighted method as the primary analytical approach based on three key assumptions underlying MR

SUBMITTER: Chen J 

PROVIDER: S-EPMC11291206 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature