Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations.

ABSTRACT: Drug administration in preclinical rodent models is essential for research and the development of novel therapies. Compassionate administration methods have been developed, but these are mostly incompatible with water-insoluble drugs such as tamoxifen or do not allow for precise timing or dosing of the drugs. For more than two decades, tamoxifen has been administered by oral gavage or injection to CreERT2-loxP gene-modified mouse models to spatiotemporally control gene expression, with the numbers of such inducible models steadily increasing in recent years. Animal-friendly procedures for accurately administering tamoxifen or other water-insoluble drugs would, therefore, have an important impact on animal welfare. On the basis of a previously published micropipette feeding protocol, we dev

SUBMITTER: Vanhecke D 

PROVIDER: S-EPMC11291282 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature